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Akihiro Onishi, Ph.D.

aki onishi

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About Me

I came from Japan and joined the Dordick lab in 2010.

I am currently a PhD student in the program of Biochemistry and Biophysics.

Former Education

B.S. in Pharmaceutical Sciences, University of Tokyo (2007)

M.S. in Pharmaceutical Chemistry, University of Tokyo (2009)

Research Interests

I am co-advised by Prof. Jonathan S. Dordick and Prof. Robert J. Linhardt.

My research focuses on the bioengineered heparin.


  1. U. Bhaskar, G. Li, L. Fu, A. Onishi, M. Suflita, J. S. Dordick, R. J. Linhardt. Combinatorial one-pot chemoenzymatic synthesis of heparin, Carbohydrate Polymers, 122, 399–407, 2015.
  2. Fu L, Zhang F, Li G, Onishi A, Bhaskar U, Sun P, Linhardt RJ. Structure and activity of a new low-molecular-weight heparin produced by enzymatic ultrafiltration. J Pharm Sci. 2014 May;103(5):1375-83.
  3. Fu L, Li G, Yang B, Onishi A, Li L, Sun P, Zhang F, Linhardt RJ. Structural characterization of pharmaceutical heparins prepared from different animal tissues. J Pharm Sci. 2013 May;102(5):1447-57.
  4. Suwan J, Torelli A, Onishi A, Dordick JS, Linhardt RJ. Addressing endotoxin issues in bioengineered heparin. Biotechnol Appl Biochem. 2012 Nov-Dec;59(6):420-428.
  5. Zhao X, Yang B, Linkens K, Datta P, Onishi A, Zhang F, Linhardt RJ. Microscale separation of heparosan, heparan sulfate and heparin. Anal Biochem. 2013 Mar 15;434(2):215-7.
  6. Bhaskar U, Sterner E, Hickey AM, Onishi A, Zhang F, Dordick JS, Linhardt RJ. Engineering of routes to heparin and related polysaccharides. Appl Microbiol Biotechnol. 2012 Jan;93(1):1-16.
  7. Wang Z, Li J, Cheong S, Bhaskar U, Akihiro O, Zhang F, Dordick JS, Linhardt RJ. Response surface optimization of the heparosan N-deacetylation in producing bioengineered heparin. J Biotechnol. 2011 Dec 10;156(3):188-96.