Clifford Steven Morrison
Office: RPI Center for Biotechnology and Interdisciplinary Studies, Rm 4139
Ph.D. Chemical and Biological Engineering, Rensselaer Polytechnic Institute, May 2020
M.S. Chemical Engineering, Rensselaer Polytechnic Institute, 2017
B.S. Chemistry, B.S. Biochemistry, University of North Texas, 2014
I will investigate the development of electrochemical bioreactors as tools for industrial fermentations and biocatalysis applications. Understanding how electrons and reducing equivalents are transported into cells is critical to engineer microorganisms to optimize carbon efficiencies and product yields. Additionally, understanding how electrochemical NAD(P)H regeneration can be efficiently achieved will allow for the development of technology that allows researchers to utilize biocatalytic processes not easily accessible because of their dependence on stoichiometric amounts of cofactor.
My project is centered around the development of a biocatalytic module for use with electrochemical bioreactors as tools for enhancing the product yield and carbon efficiency in industrial biocatalysis processes relying on NAD(P)H. Additionally, understanding how electrochemical NAD(P)H regeneration can be efficiently achieved will allow for the development of technology that allows researchers to utilize biocatalytic processes not easily accessible because of their dependence on stoichiometric amounts of cofactor. My primary interest is in the sustainable production of value-added products and energy using metabolic engineering and biotechnology. I intend to pursue a career in the biotechnology industry, or as a faculty member in academia.
Clifford S. Morrison, Marvin A. Rios, Thomas R. Beusse, Elaina M. Blair, Lucy Q. Lin, James R. Hu, Aidan H. Gorby, Jonathan S. Dordick, Mattheos A. G. Koffas. “Improved Soluble Expression of Recombinant Human Renalase Isoform 1 for the Development of a Renalase Bioreactor.” In preparation.
Clifford S. Morrison, Elizabeth Heitmann, William Armiger, David Dodds, and Mattheos Koffas. "Electrochemical Bioreactor Technology for Biocatalysis and Microbial Electrosynthesis." Advances in Applied Microbiology, volume 105, 2018.
Clifford S. Morrison, William B. Armiger, David R. Dodds, Jonathan S. Dordick, and Mattheos A. G. Koffas. “Improved strategies for electrochemical 1,4-NAD(P)H2 regeneration: A new era of bioreactors for industrial biocatalysis.” Biotechnology Advances, 2018.
Clifford S. Morrison, “Utilizing electrochemical bioreactors for efficient chemical and biological applications.” Rensselaer Polytechnic Institute, Troy, NY, 2017. Rensselaer Digital Collections, EBSCOhost, 2017.
Clifford S. Morrison, Jana B. Lampe, Tesia C. Kolodziejczyk, Ronaldo J. Cavazos, and Robby A. Petros. "Rapid, Quantitative, Solvent-Free Synthesis of Medium-Ring Diaza Heterocycles from Diketene-Acetone Adduct and Diamines." Tetrahedron Letters, 2014.
Clifford S. Morrison, David R. Dodds, William B. Armiger, Jonathan S. Dordick, and Mattheos A. G. Koffas. "Improved Method for Using Electrochemical Bioreactor Module with Recovery of Cofactor." World Intellectual Property Organization WO/2017/160793, filed March 14, 2017.
Robby A. Petros, Duong T. Nguyen, Ronaldo J. Cavazos, Clifford S. Morrison, Jana B. Lampe, and Alesha N. Harris. "Synthesis and Use of Prodrug Complexes of Cobalt in Polymer Therapeutics." U.S. Patent 20,150,299,238 issued October 22, 2015.
I intend to pursue a career in the biotechnology industry, or as a faculty member in academia.