Matthew Brier, Postdoc
I joined RPI in the Fall of 2009 to pursue to my undergraduate studies in Chemical Engineering. After doing research in a number of different labs I found I liked research at RPI enough that I wanted to stick around and pursue my graduate studies in Chemical Engineering. For the past two years, I have worked in Prof. Dordick’s group studying the in vitro remote stimulation and control of cellular response using magnetic nanoparticles.
Ph.D. in Chemical Engineering, Rensselaer Polytechnic Institute, May 2020
M.S. in Chemical Engineering, Rensselaer Polytechnic Institute, Dec 2015
B.S. in Chemical Engineering, Rensselaer Polytechnic Institute, May 2013
B.S. in Mathematics, Rensselaer Polytechnic Institute, May 2013
There has been extensive research into the structure, function, and activation of ion channels. The transient receptor potential vanilloid 1 (TRPV1) cation channel is one such channel which has been found to be sensitive to mechanical, thermal, electrical, and chemical stimulation. By stimulating this channel, calcium ion (Ca2+) flux into the cell can be controlled and used to modulate Ca2+-dependent cellular pathways. As such, my research focuses on tethering magnetic nanoparticles to TRPV1 and using electromagnetic radiation to remotely transduce channel activation. By introducing modified TRPV1 designed to tether to endogenous ferritin nanoparticles, an iron binding protein nanocage with superparamagnetic properties, cellular activity can be controlled in vitro and in vivo to induce gene response, protein production, and cell signaling. If successful, this magnetic gene platform could be used as a novel therapeutic for the treatment of various chronic neurological illnesses for which there are currently no cures.
Publications & Presentations
Wang, Q.; Brier, M.; Joshi, S.; Puntambekar, A.; Chakrapani, V. Defect-induced Burstein-Moss shift in reduced V2O5 nanostructures. Phys. Rev. B. 2016, 94, 245305.
Chakrapani, V.; Brier, M.; Puntambekar, A.; DiGiovanni, T. Modulation of stoichiometry, morphology and composition of transition metal oxide nanostructures through hot wire chemical vapor deposition. J. Mater. Res. 2016, 31, 17-27.
Patke, S.; Boggara, M.; Maheshwari, R.; Srivastava, S.K.; Arha, M.; Douaisi, M.; Martin, J.T.; Harvey, I.B.; Brier, M.; Rosen, T.; Mogridge, J.; Kane, R.S. Design of Monodisperse and Well-Defined Polypeptide-Based Polyvalent Inhibitors of Anthrax Toxin. Angew. Chem. 2014, 126, 8172-8778.
Patke, S.; Boggara, M.; Maheshwari, R.; Srivastava, S.K.; Arha, M.; Douaisi, M.; Martin, J.T.; Harvey, I.B.; Brier, M.; Rosen, T.; Mogridge, J.; Kane, R.S. Design of Monodisperse and Well-Defined Polypeptide-Based Polyvalent Inhibitors of Anthrax Toxin. Angew. Chem. Int. Ed. 2014, 53, 8037-8040.
Patke, S.; Maheshwari, R.; Boggara, M.; Srivastava, S.; Arha, M.; Martin, J.T.; Brier, M.; Harvey, I.B.; Kane, R. Design of monodisperse polypeptide-based polyvalent inhibitors of anthrax toxin. Presented at the 245th American Chemical Society National Meeting & Exposition, New Orleans, Louisiana, USA, April 7-11, 2013; Paper BIOT 52.
Awards & Honors
- Isermann Fellowship, 2013
- Omega Chi Epsilon, 2012
- Tau Beta Pi, 2011
- Rensselaer Medal, 2009
Hobbies & Activities
I am an avid reader. I enjoy an engrossing book on nature, science, or history as well as the occasional science fiction and fantasy novel. I am also a table top miniatures gamer, building and painting models which I use in competitive strategy games such as Warmachine & Hordes.