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Paiyz E. Mikael

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About Me

Originally from Kurdistan (northern Iraq), I migrated to USA in 1997. First in my immediate and extended family to earn a PhD. I joined Dr. Dordick and Dr. Linhardt groups in 2015. My previous work focused on developing various 3D matrices from synthetic and natural polymers and hydrogels alone or in combination with carbon nanotubes and magnesium to address different challenges in the regeneration of segmental bone defects.

Former Education

2015, Ph.D. in Material Science and Engineering, University of Connecticut “GO HUSKIES”
2010, M.S. in Biomedical Engineering, University of Connecticut, “GO HUSKIES”
2003, B.A. in Biology, Southern Connecticut State University

Research

My research focuses on two areas: I) developing advanced biomaterials with micro and nanoscale technologies to control cellular microenvironments for the regeneration of complex tissues/organs. II) Examine the effect of temporal remodeling of glycosaminoglycans (GAGs) on stem cell migration, proliferation, cell fate and maintenance of long-term functionality.

Publications

Peer Reviewed Publications

  1. Yu Y., Chen Y., Mikael P., Zhang F., Stalcup AM., German R., Gould F., Ohlemacher J., Zhang H., Linhardt RJ., Surprising absence of heparin in the intestinal mucosa of baby pigs, Glycobiology. 2016 [PMID: 27744271]
  2. Mikael PE., Kim HS., Nukavarapu SP., Hybrid Extracellular Matrix Design for Cartilage-Mediated Bone Regeneration, JBMR Part B, 2017 [PMID:28140522]
  3. Mikael PE. Xin X., Urso M., Jiang X., Wang L., Barnes B., Lichtler AC, Rowe DW. & Nukavarapu SP., A Potential Translational Approach for Bone Tissue Engineering Through Endochondral Ossification. Conf Proc IEEE Eng Med Biol Soc. 2014, Aug; 2014:3925-8.
  4. Mikael PE. Amini AR., Basu J., Arellano-Jimenez MJ., Laurencin CT., Sanders MM., Carter B., & Nukavarapu SP., Functionalized carbon nanotube reinforced scaffolds for bone regenerative engineering: Fabrication, in vitro, and in vivo evaluation, Biomed Mater. 2014 Mar 31; 9(3):035001.
  5. Igwe J., Mikael PE., & Nukavarapu S. P., Design, Fabrication, and in vitro Evaluation of a Novel Polymer-Hydrogel Hybrid Scaffold for Bone Tissue Engineering, J Tissue Eng Regen Med. 2012; 8(2):131-42.
  6. Mikael PE. & Nukavarapu SP., Functionalized Carbon Nanotube Composite Scaffolds for Bone Tissue Engineering: Prospects and Progress. J. Biomater. Tissue Eng. 2011; 1(1):76-85.

Book Chapters

  1. Mikael PE. & Nukavarapu SP., Cell-Based Approaches for Bone Regeneration. In Laurencin C. T., ed. Bone Graft Substitutes: ASTM International accepted 2014.
  2. Mikael PE., Wallace J. A., & Nukavarapu S. P., Nanotubes for tissue engineering. In Webster T., ed. Nanomedicine: Technologies and applications: Woodhead Publishing, 2012: 460-489.
  3. Igwe J., Amini A., Mikael P., Laurencin C. T., & Nukavarapu S. P., “Nanostructured Scaffolds for Bone Tissue Engineering". In Zilberman M, ed. Active Implants and Scaffolds for Tissue Regeneration: Springer, 2011: 169-92.

Awards and Honors

  • Academic Achievement Award: Outstanding Woman Scholar, University of Connecticut, 2015
  • Doctoral Dissertation Fellowship Award, University of Connecticut, 2014
  • Women of Innovation Finalist, Connecticut Technology Council, 2013
  • NSF-GK12 Graduate Fellowship, University of Connecticut, 2010-2012
  • CuraGen Scholar Award, CuraGen INC., 2002

Hobbies and Activities

Hiking and dancing with my kids, playing badminton, volleyball and backgammon, and jewelry making.