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About me

I am from Soissons, small town in France and I joined Pr. Siegel’s and Pr. Dordick’s group in February 2011.

Former Education

2011-2013: Post-doctoral Research associate at RPI.

2007-2010: Ph.D in Biology and Medical Sciences, INSERM U957, University of Nantes, France. Thesis title: “Interaction between stem cells and nanostructured implanted surface”

2006-2007: Master 2 Research. Sc. in Biomolecule and Cell Dynamic. University of Reims, France. Report title: “effect of thalidomide on MDR1 expression in sensible and resistant myeloma cells”.

2005-2006: Master 1 in Biochemistry. University of Reims, France. Project title: “Sifting by dHPLC and capillary Sequencing: Interest for the study of BRCA1 polymorphism”.

Research

My research is focused on the cell-nanosubstrate interaction. Our studies involve Mesenchymal and Embryonic Stem Cells for a better understanding on the mechanism of adhesion and differentiation of Stem Cells on well-control nanostructured surface. For this, nanostructured surface were obtained by oblique-angle deposition of SiO2 and TiO2 and characterized.

Publications

Trussardi-Regnier A, Lavenus S, Gorisse MC, Dufer J. “Thalidomide alters nuclear architecture without ABCB1 gene modulation in drug-resistant myeloma cells” Int J Oncol. 2009 Sep;35(3):641-7.

Lavenus S., Ricquier J. C., Louarn G., Layrolle P. “Cell interaction with nanopatterned surface of implants” Nanomedicine, August 2010, Vol. 5, No. 6, Pages 999-1007.

Lavenus S., Louarn G., Layrolle P. “Nanotechnology and dental implants” Int J Biomater. 2010;2010:915327. Epub 2010 Dec 28.

Lavenus S., Pilet P., Weiss P., Guicheux J., Louarn G., Layrolle P.. “Behaviour of mesemchymal stem cells on smooth surface” Acta Biomaterialia. 2011 Apr;7 (4):1525-34.

Lavenus S., Berreur M., Trichet V., Pilet P., Louarn G., Layrolle P. “Adhesion and osteogenic differentiation of human mesenchymal stem cells on titanium nanopores” Eur Cell Mater. 2011 Aug 26; 22:84-96

Lavenus S., Lechevalier S., Amiaud J., Hoorneart A., Louarn G., Layrolle P. “Cell differentiation and osteointegration influenced by nanoscale anodized titanium surfaces” Nanomedicine, 2012.