I completed my high school education in Mumbai, India. I then attended San Jose State University, San Jose, CA to complete my Bachelors degree in Chemical Engineering (graduated 2007). I joined RPI in 2008 for pursuing my doctoral studies in Chemical Engineering.
San Jose State University, San Jose, CA, Bachelor of chemical engineering, 2007
My research revolves around protein conformational disorders such as Alzheimer's disease. Substantial evidence suggests that prefibrillar oligomers are the most toxic aggregated species. To what extent such oligomers can be selectively targeted and remodeled into non-toxic conformers using small molecules is poorly understood. My research has tried to evaluate the remodeling pathways employed by a diverse panel of aromatic small molecules against toxic oligomers of the Aβ 42 peptide associated with Alzheimer's disease. It has been found that small molecule antagonists can be grouped into three classes based on the distinct pathways they utilize to remodel Aβ oligomers into multiple conformers with reduced toxicity. Relatively subtle differences in small molecule structure encipher dramatic differences in the pathways they employ to remodel toxic Aβ soluble oligomers.