Background

Chemical Engineering BSc (May, 2003).

Department of Chemical and Biological Engineering, College Of Chemistry, University of California at Berkeley, Berkeley, CA 94720

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Research area

I am co-advised by Professors Dordick and Bystroff (Biology Department). My research focuses on structure-based protein design for stability and biocatalytic specificity. The tools I use are protein modeling, bioinformatics, and microbiology to test those designs. The hypothesis of this work is that in many proteins, secondary structure packing and alignment are what primarily confer function and that protein stability (in particular the rate of protein unfolding and possibly stability) can be engineered by manipulating protein topology and secondary structure connections. Methods and principles learned will be applied in the future to effecting biocatalytic specificity and stability.

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Publications

Lee M.Y., Park C.B., Dordick J.S. and Clark D.S. (2005). Metabolizing enzyme toxicology assay chip (MetaChip) for high-throughput microscale toxicity analyses. PNAS USA. 102, (4), 983-987. (acknowledgement)

DiTursi M.K., Kwon S.J., Reeder P.J., and Dordick J.S. (2006).  Bioinformatics-driven, rational engineering of protein thermostability.  Protein Engineering, Design & Selection, 19, (11), 517-524.

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Research Highlights

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Honors & Awards

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