Background

EDUCATION

B.E., Chemical Engineering

Malaviya National Institute of Technology, Jaipur, India, May 2003 [Graduated with Honors]. 

Ph.D., Chemical and Biological Engineering

Rensselaer Polytechnic Institute (RPI), Troy, NY, October 2007 [GPA: 3.6].       

PROFESSIONAL EXPERIENCE

October 2007–Present               Postdoctoral Scientist, Solidus Biosciences, Inc., Troy, NY

October 2007–Present               Visiting Scholar, RPI, Troy, NY

June 2004–October 2007           Research Assistant, RPI, Troy, NY

August 2003–May 2004             Howard P. Issermann Fellow, RPI, Troy, NY

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Research area

CURRENT RESEARCH INTERESTS

-     High-throughput biocatalysis on biochips for microscale toxicity analyses. 

High-throughput screening, CYP450 activity and inhibition, in vitro cytotoxicity and metabolism-induced toxicity.

-     Design of antimicrobial and self-cleaning polymer-enzyme composite films and coatings.

Polymer-enzyme composites, chemical modification of enzymes, enzymes in organic solvents, inhibition of microbial contamination of surfaces.

THESIS DISSERTATION

-     Engineering protein activity and stability through control of the nanoscale environment.

Nanobiotechnology, protein structure and function, aqueous and non-aqueous biocatalysis, polymer nanocomposites, nano- and microscale self-assembly, biphasic biocatalysis, biomineralization.

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Publications

JOURNAL ARTICLES

13. Padala, C.; Asuri, P.; Litt, J.; Parasharan, K.; Vutukuru, S.; Dordick, J. S.; Kumar, S.; Kane, R. S.; Activity and Stability of Enzymes Adsorbed onto Homogeneous and Heterogeneous Liposomes, Manuscript in Preparation (2007).

12. Goswami, S.; Bajwa, N.; Ci, L.; Asuri, P.; Ajayan, P.; Cramer, S. Aligned Carbon Nanotube Stationary Phases for Electrochromatographic Chip Separations, Manuscript in Preparation (2007).

11. Karajanagi, S. S.; Asuri, P.; Sellitto, E.; Eker, B.; Bale, S. S. Kane, R. S.; Dordick, J. S. Protein-Carbon Nanotube Conjugates, ACS Symposium Series, Manuscript in Press (2007).

10. Asuri, P.; Bale, S. S.; Pangule, R. C.; Shah, D. A.; Kane, R. S.; Dordick, J. S. Structure, Function, and Stability of Enzymes Covalently Attached to Single-Walled Carbon Nanotubes, Langmuir, 23, 12318-12321 (2007).

9. Bale, S. S.; Asuri, P.; Karajanagi, S. S.; Dordick, J. S.; Kane, R. S. Protein-Directed Formation of Silver Nanoparticles on Carbon Nanotubes, Advanced Materials, 19, 3167-3170 (2007).

8. Eker, B.; Asuri, P.; Murugesan, S.; Linhardt, R. J.; Dordick, J. S. Enzyme-Carbon Nanotube Conjugates in Room Temperature Ionic Liquids, Applied Biochemistry and Biotechnology, 143, 153-163 (2007).  

7. Asuri, P.; Karajanagi, S. S.; Vertegel, A. A; Dordick, J. S.; Kane, R. S. Enhanced Stability of Enzymes Adsorbed onto Nanoparticles, Journal of Nanoscience and Nanotechnology, 7, 1675-1678 (2007).

6. Asuri, P.; Bale, S. S.; Karajanagi, S. S.; Kane, R. S. The Protein-Nanomaterial Interface, Current Opinion in Biotechnology, 17, 562-568 (2006).

5. Asuri, P.; Karajanagi, S. S.; Sellitto, E.; Kim, D. –Y.; Kane, R. S.; Dordick, J. S. Water-Soluble Carbon Nanotube-Enzyme Conjugates as Functional Biocatalytic Formulations, Biotechnology and Bioengineering, 95, 804-811 (2006).

4. Asuri, P.; Karajanagi, S. S.; Yang, H.; Yim, T. -J.; Kane, R. S.; Dordick, J. S. Increasing Protein Stability Through Control of the Nanoscale Environment, Langmuir, 22, 5833-5836 (2006).

3. Asuri, P.; Karajanagi, S. S.; Dordick, J. S.; Kane, R. S. Directed Assembly of Carbon Nanotubes at Liquid-Liquid Interfaces: Nanoscale Conveyors for Interfacial Biocatalysis, Journal of American Chemical Society, 128, 1046-1047 (2006).

2. Asuri, P.; Karajanagi, S. S.; Kane, R. S.; Dordick, J. S. Polymer-Nanotube-Enzyme Composites as Active Antifouling Surfaces, Small, 3, 50-53 (2006). (Highlighted in Nature Nanotechnology)

1. Karajanagi, S. S.; Yang, H.; Asuri, P.; Sellitto, E.; Dordick, J. S.; Kane, R. S. Protein-Assisted Solubilization of Single-Walled Carbon Nanotubes, Langmuir, 22, 1392-1395 (2006).

PATENTS

1. Asuri, P.; Dordick, J. S.; Kane, R. S. Karajanagi, S. S.; Enhanced Stability of Proteins Immobilized on Carbon Nanotubes, Patent Pending.

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Research Highlights

Postdoctoral Scientist at Solidus Biosciences, Inc.

Increasing the efficiency and effectiveness of drug development by providing proprietary decision-enabling technology for high-throughput toxicology assays and lead optimization conducted throughout the discovery and preclinical phases of new drug development.

Research Assistant at Rensselaer Polytechnic Institute

Preparation and characterization of highly active and stable carbon nanotube-enzyme conjugates for the design of applications in biocatalysis and biotransformations and for the generation of self-cleaning polymer-nanocomposites and other hybrid materials that integrate abiotic and biotic components.

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Honors & Awards

Founders Award of Excellence, – ‘Award given to the best and brightest’ at RPI [2006].

Best Poster Award, AIChE Annual Meeting, Cincinnati, OH [2005].

Best Poster Award, NY Nanotech Meeting, Albany, NY [2004].

Howard P. Isermann Graduate Fellowship, RPI [2003].

Best Poster Award, IIM Annual Meeting, NMD-ATM, India [2002].

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