| Senior Research Specialist | |
| Office: | Biotech Building 4117 |
| Telephone: | 518-276-4216 |
| Fax: | 518-276-2207 |
| E-mail: | brooks@rpi.edu |
| Mailing
Address: |
Dept. of Chemical
and Biological Engineering Rensselaer Polytechnic Institute Center for Biotechnology and Interdisciplinary Studies, Room 4211 110 8th Street Troy, NY 12180-3590 |
| Background | Research Area | Publications | Highlights | Honors | |
BSc (June, 1999) and Ph.D
(November
2003).
and Biomedical Research, University College Dublin, Belfield, Dublin 4, Republic of Ireland.
My research in the Dordick group focuses on solid phase biocatalysis for drug discovery. This involves the attachment and transformation of substrates on solid supports such as glass beads or polymeric materials followed by biotransformations of these bound substrates. This may be of use as a follow up from screened “hits” on microarrays, whereby a desired reaction can be scaled up to produce the desired product in larger amounts. The solid phase approach, however, may itself be used to generate libraries of compounds through iterative and combinatorial biotransformations of attached lead compounds.
O'Kiely, P., Brooks, S.J
and Doyle,
E.M. (1999). Grass ensilability in
response to incremental concentrations of nitrate.
Irish Journal of Agricultural and Food
Research, 38, (2), 273-274.
Brooks, S.
J, Doyle, E. M, Hewage, C, Malthouse, J. P. G, Duetz, W. and O’Connor,
K. E
(2004). Biotransformation of
halophenols using crude cell extracts of Pseudomonas
putida F6. Applied Microbiology and
Biotechnology. 64,
486-492.
Brooks, S. J, Doyle, E. M
and O’Connor K. E. (2006). Tyrosol to hydroxytyrosol
biotransformation by immobilised cell extracts
of Pseudomonas putida F6. Enzyme and Microbial Technology. 39,
191-196.
Mc Mahon, A. M. Doyle, E.
M,
Brooks, S. J. and O’Connor K. E. (2006). Biochemical
characterisation
of the coexisting tyrosinase and laccase in the soil bacterium Pseudomonas putida F6. Enzyme and Microbial
Technology. In Press,
Accepted Manuscript, Available
online
Brooks, S.
J, Doyle, E. M, O’Sullivan, T, Guiry, P. J, Li, Z. and O’Connor K. E Ring and
side chain oxidation of 4-substituted phenols by mushroom tyrosinase
and cell
extracts of P. putida F6. Applied Microbiology and
Biotechnology
In Press, Accepted Manuscript.
Enterprise Ireland
Research
Scholarship, 1999-2002
Irish Environmental
Protection
Agency Contributory Scholarship, 2000-2002
Society for General
Microbiology
Presidents Award, 2002