A team from Rensselaer Polytechnic Institute and Albany Medical College has been awarded a $500,000 grant to carry out research for the development of a Pentosan Polysulfate (PPS)-based nasal spray to block COVID-19.

Rensselaer Professor Jonathan Dordick and collaborators from Rensselaer Polytechnic Institute and Albany Medical College have been awarded $500,000 from the New York State Biodefense Commercialization Fund to engage in research for the development of a P

CRISPR-based detection of target DNA or RNA exploits a dual function, including target sequence-specific recognition followed by trans-cleavage activity of a collateral ssDNA linker between a fluorophore (F) and a quencher (Q), which amplifies a fluorescent signal upon cleavage. In this work, we have extended such dual functionality in a modified immunoassay format to detect a target protein, CXCL9, which is markedly elevated in the urine of kidney transplant recipients undergoing acute rejection episodes.
TROY, N.Y. — Jonathan Dordick, the Howard P. Isermann ’42 Professor of Chemical and Biological Engineering at Rensselaer Polytechnic Institute, has been elected to the National Academy of Engineering (NAE), for his “contributions to methods for rapidly screening drug efficacy and toxicity, and biocatalytic technologies for improving human health.”
Do we already have the powerful drugs we need to treat COVID-19? Maybe. In order to find out, we will also need a clearer perspective and fuller understanding of the drug repurposing process.

Using full-length NSH, containing different amounts of N-acetylglucosamine (GlcNAc) residues, we demonstrate that C5-epimerase specificity relates to polysaccharide sequence, particularly the location of GlcNAc residues within the chain.

In a test of antiviral effectiveness against the virus that causes COVID-19, an extract from edible seaweeds substantially outperformed remdesivir, the current standard antiviral used to combat the disease. Heparin, a common blood thinner, and a heparin variant stripped of its anticoagulant properties, performed on par with remdesivir in inhibiting SARS-CoV-2 infection in mammalian cells. Published online today in Cell Discovery, the research is the latest example of a decoy strategy researchers from the Center for Biotechnology and Interdisciplinary Studies (CBIS) at Rensselear Polytechnic Institute are developing against viruses like the novel coronavirus that spawned the current global health crisis.

New approach could be used to detect and kill viruses in the bloodstream

By folding snippets of DNA into the shape of a five-pointed star using structural DNA nanotechnology, researchers have created a trap that captures Dengue virus as it floats in the bloodstream.

Greater understanding of phenomena could enable unprecedented control over gene expression

A Lego-Like Approach to Improve Nature’s Own Ability to Kill Dangerous Bacteria

Research capitalizes on ability of enzymes to target and kill bacteria, improving possible solution to problem of antibiotic resistance.

Jonathan Dordick Received Amgen Biochemical and Molecular Engineering Award

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