Patents | The Dordick Research Lab

50.	R.J. Linhardt, J.S. Dordick, Y. Yu, L. Fu, P. He, K. Xia, S. Varghese, F. Zhang (2022), “Chemoenzymatic Synthesis of Low Molecular Weight Heparin from Low Molecular Weight Heparosan”, Provisional Application.
49.	R.J. Linhardt, S.Y. Kim, W. Jin, J.S. Dordick, F. Zhang, S.J. Kwon, P. Kwon, and K. Fraser (2021), “Compositions Incorporating Sulfated Polysaccharides for Inhibiting SARS-CoV-2”, PCT Filed.
48.	X. Wang, S.J. Kwon, J.S. Dordick, R.J. Linhardt, and P.S. Kwon (2021), “DNA Nanoarchitectures for Pattern-Recognized Targeting of Diseases”, PCT US2020/033398.
47.	S.J. Kwon, J.S. Dordick, S. Gopal, and B. Ku (2021), “Methods of Three-Dimensional Tumor Spheroid Microarray for High-Throughput, High-Content Immune Cell-Mediated Cytotoxicity”, U.S. Patent Pending.
46.	S.J. Kwon, R.J. Linhardt, J.S. Dordick, W.J. Sonstein, F. Zhang (2021), “Detection of Cerebrospinal Fluid”, U.S. Patent 11,067,581.
45.	S.J. Kwon, J.S. Dordick, R.J. Linhardt, M.G. Kim, J. Oh, W.J. Sonstein (2019), “Detection of Cerebrospinal Fluid”, PCT/US16/38062.
44.	L. Fu et al. (2019), “Enzymatic Preparation of Increased Anticoagulant Bovine Sourced Heparin”, PCT/US18/23394.
43.	M. Douaisi, N. Grover, P. Datta, E. Paskaleva, P. Brodfuehrer, T.J. Simmons, A. Onishi, M. Hirakane, L. Fu, K. Li, R.J. Linhardt, and J.S. Dordick (2019), “Biosynthetic Heparin, PCT/US17/50385.
42.	L. Fu et al. (2018), “Enzymatic Preparation of Anticoagulant Bovine Sourced Heparin”, PCT Application. 2018005005.
41.	L. Fu et al. (2018), “Biosynthetic Heparin, PCT/US17/5038.
40.	X. Qian, J.E. Gagner, J.S. Dordick, and R.W. Siegel (2016), “Internalization of Proteins into Hollowed Gold Nanostructures,” U.S. Patent 9,562,225.
39.	J.S. Dordick, R.S. Kane, P. Asuri, S.S. Karajanagi, A.A. Vertegel, and R.W. Siegel (2016), “Enhanced Stability of Proteins Immobilized on Nanoparticles,” U.S. Patent 9,360,475.
38.	M. Miyauchi, J. Miao, T.J. Simmons, J.W. Lee, T.V. Doherty, J.S. Dordick, and R.J. Linhardt (2015), “Cellulose Sheathed Nanotube Fiber,” U.S. Patent 9,061,904.
37.	S.A. Stanley, J.M. Friedman, J.S. Dordick, and J. Sauer (2014), “Compositions and Methods to Modulate Cell Activity”, U.S. Patent Application 201462053602.
36.	Z. Wang, R.J. Linhardt, J.S. Dordick, and U. Bhaskar (2014), “K5 Heparosan Fermentation and Purification”, U.S. Patent 8,883,452.
35.	R.J. Linhardt, J.S. Dordick, T.J. Simmons, M. Miyauchi, and S.H. Lee (2014), “Synthetic Wood Composite”, U.S. Patent 8,772,406.
34.	M.Y. Lee, A.K. Ramasubramanian, D.S. Clark, and J.S. Dordick (2012), “Three-Dimensional Cellular Array Chip and Platform for Toxicology Assays, Canadian Patent 2,628,219; Japanese Patent 4,959,710.
33.	K. Rege, S. Hu, J.S. Dordick, and S.M. Cramer (2008), “Aminoglycoside-Polyamine Displacers and Methods of Use in Displacement Chromatography”, U.S. Patent 7,439,343.
32.	J.S. Dordick and D.S. Clark (2010), “Biocatalytic Sol-Gel Microarrays”, U.S. Patent 7,846,747; Canadian Patent 2,466,172; Japanese Patent 4,365,216.
31.	J.S. Dordick, A. Srinivasan, J. Kim, D. Sherman, and D.S. Clark (2008), “In vitro Metabolic Engineering on Microscale Devices”, U.S. Patent 7,427,497.
30.	J.S. Dordick, M.-Y. Lee, A. Srinivasan, and B. Ku (2007), “Enzyme Immobilization for Electroosmotic Flow”, U.S. Patent 7,172,682.
29.	J.S. Dordick, L. Santhanam, M. Hogg, and J.A. Holland (2007), “Solid-Phase Array-Based Biocatalytic Transformations “, U.S. Patent 7,202,030.
28.	J.S. Dordick and D.S. Clark (2007), “Biocatalytic Sol-Gel Microarrays”, U.S. Patent 7,267,958.
27.	S.M. Cramer, K. Rege, and J.S. Dordick (2005), “High-throughput screening of potential displacer molecules”, U.S. Patent 6,881,540.
26.	M. A. Markowitz, P. E. Schoen, B. P. Gaber, B. R. Ratna, P. R. Kust, D. C. Turner, D. S. Clark, and J. S. Dordick (2003), “Molecularly-Imprinted Material Made by Template-Directed Synthesis”, U. S. Patent 6,660,780.
25.	M. A. Markowitz, P. E. Schoen, B. P. Gaber, B. R. Ratna, P. R. Kust, D. C. Turner, D. S. Clark, and J. S. Dordick (2004), “Molecularly-Imprinted Material Made by Template-Directed Synthesis”, U. S. Patent 6,713,416.
24.	M. A. Markowitz, P. E. Schoen, B. P. Gaber, B. R. Ratna, P. R. Kust, D. C. Turner, D. S. Clark, and J. S. Dordick (2003), “Molecularly-Imprinted Material Made by Template-Directed Synthesis”, U. S. Patent 6,660,780.
23.	M. A. Markowitz, P. E. Schoen, B. P. Gaber, B. R. Ratna, P. R. Kust, D. C. Turner, D. S. Clark, and J. S. Dordick (2003), “Molecularly-Imprinted Material Made by Template-Directed Synthesis”, U. S. Patent 6,583,191.
22.	J. S. Dordick, J. Kim, and X. Wu (2002), "Sensing Array and Sensor Structure", U. S. Patent 6,406,668.
21.	Y.L. Khmelnitsky, C.L. Budde, J.M. Arnold, J.O. Rich, S.S. Chen, A.Y. Usyatinsky, D.S. Clark, and J.S. Dordick (2001), “Two-step enzymatic acylation”, U.S. Patent 6,261,813.
20.	M. A. Markowitz, P. E. Schoen, B. P. Gaber, B. R. Ratna, P. R. Kust, D. C. Turner, D. S. Clark, and J. S. Dordick (2001), “Molecularly-Imprinted Material Made by Template-Directed Synthesis”, U. S. Patent 6,310,110.
19.	J.S. Dordick, P. Wang, M.V. Sergeeva, and S.J. Novick (2001), “Polymer-protein composites and methods for their purification and use”, U.S. Patent 6,291,582.
18.	J.S. Dordick, D.S. Clark, P.C. Michels, and Yu.L. Khmelnitsky (2002), “Taxol derivatives”, U.S. Patent 6,465,625.
17.	J.A. Akkara, D.L. Kaplan, F.F. Bruno, and J.S. Dordick (2001), “Transesterification of Insoluble Polysaccharides”, U.S. Patent 6,228,997.
16.	J.S. Dordick, V. M. Paradkar, and M.V. Sergeeva (2001), “Enzyme catalysis in organic solutions containing water”, U.S. Patent 6,171,813.
15.	J.S. Dordick, D.S. Clark, P.C. Michels, and Y.L. Khmelnitsky (2000), “Biocatalytic methods for synthesizing and identifying biologically active compounds”, U.S. Patent 6,136,961.
14.	J.A. Akkara, D.L. Kaplan, F.F. Bruno, and J.S. Dordick (2000), “Transesterification of Insoluble Polysaccharides”, U. S. Patent 6,063,916.
13.	J. S. Dordick, P. Wang, M. V. Sergeeva, and S. J. Novick (1999). “Biocatalytic Plastics”, U. S. Patent 5,914,367.
12.	J. S. Dordick, D. G. Rethwisch, and D. R. Patil (1998), "Sugar-Based Polymers", Canadian Patent 2,088,366.
11.	J. S. Dordick, R. J. Linhardt, and B. D. Martin (1998). "Sugar-Based Hydrogels", U.S. Patent 5,854,030.
10.	J. S. Dordick and V. M. Paradkar (1998). "Enzyme-Surfactant Ion-Pair Complex Catalyzed Reactions in Organic Solvents ", U. S. Patent 5,719,039.
9.	J. S. Dordick, D. G. Rethwisch, and D. R. Patil (1997), “Sugar-Based Polymers”, U. S. Patent 5,618,933.
8.	J. S. Dordick. B.D. Martin, and R.J. Linhardt (1995). "Method of Making Poly(Sugar Acrylates) Using Hydrolytic Enzymes", U. S. Patent 5,474,915.
7.	J. S. Dordick, Y. L. Khmelnitsky, and D. S. Clark (1995). "Reacting an Enzyme in a Non-Aqueous Solvent by Adding a Lyophilizate of Enzyme and Salt to the Solvent", U. S. Patent 5,449,613.
6.	J. S. Dordick, A. J. Hacking, and R.A. Khan (1993). “Sucrose 6,4'-Dicarboxylic Esters”, U. S. Patent 5,270,460.
5.	J. S. Dordick, D. G. Rethwisch, and D. R. Patil (1993). "Sugar-Based Polymers", U. S. Patent 5,270,421.
4.	S. Bornemann, J.M. Cassells, C.L. Combes, J.S. Dordick, and A.J. Hacking (1992). "Preparation of Acylated Sucrose Derivatives", U.S. Patent 5,141,860.
3.	J.S. Dordick, A.J. Hacking, and R.A. Khan (1992). "Selective Acylation of Sugars", U.S. Patent 5,128,248; Great Britain Patent 2,224,733; Japanese Patent 2,758,941.
2.	E.B. Rathbone, K.S. Mufti, R.A. Khan, P.S.J. Cheetham, A.J. Hacking, and J.S. Dordick (l989). "Tetrachlororaffinose and its Use in the Preparation of Sucralose", U.S. Patent 4,826,962; Great Britain Patent 2,181,734; Canadian Patent 1,282,728.
1.	A. M. Klibanov and J. S. Dordick (1989). "Enzymatic Temperature Change Indicator", U.S. Patent 4,826,762.