I had the honor of joining the Dordick Lab in August 2022, following a rewarding research journey that began in Linhardt's Lab at RPI back in October 2019. My research background spans various domains, including small-molecule natural products in marine invertebrates, cellular biology, and macromolecules, with a specialization in polysaccharides. With over a decade of experience in polysaccharide studies, I have developed a strong proficiency in tailoring technical approaches to separate, purify, and analyze target polysaccharides, adapting methods to the unique characteristics of diverse biological samples. Currently, my research centers on glycan purification, quantification, compositional and structural characterization, protein-glycan interaction, and glycomaterials development. Beyond the lab, I find enjoyment in hiking and baking during my spare time.
Education and Research Experience
Postdoctoral Research Associate, 2021 – Present, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, U.S.
Visiting Scholar, 2019 – 2021, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, New York, U.S.
Ph.D. in Biochemical Engineering, 2011, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
B.S. in Marine Biology, 2003, College of Oceanography and Environment, Xiamen University, Xiamen, China
My research interests lie in the following aspects:
(1) The purification and analysis of polysaccharides from complicated biological specimens.
(2) The elucidation of the structure and biofunctional roles of polysaccharides and polysaccharide-conjugates.
(3) Understanding the molecular mechanisms of polysaccharides’ interactions with other macro-biomolecules.
(4) The physicochemical and biofunctional characterization of polysaccharide-based biomaterial candidates.
Hoffman E, Song Y, Zhang F, Asarian L, Downs I, Young B, Han X, Ouyang Y, Xia K, Linhardt RJ, Weiss DJ. (2023). Regional and disease-specific glycosaminoglycan composition and function in decellularized human lung extracellular matrix. Acta Biomaterialia, 168, 388-399.
Song Y, Kouta A, Cera LM, Xia K, Zhang F, Kraemer R, Fareed J, Linhardt RJ, Jeske W. (2023). Absolute pharmacokinetics of heparin in primates. Carbohydrate Polymers, 311, 120779.
Mahbuba DA, Masuko S, Wang S, Syangtan D, Kang JS, Song Y, Shin TW, Xia K, Zhang F, Linhardt RJ, Boyden ES, Kiessling LL. (2023). Dynamic changes in heparan sulfate nanostructure in human pluripotent stem cell differentiation. ACS nano, 17(8), 7207-7218.
Shi D, Bu C, He P, Song Y, Dordick JS, Linhardt RJ, Chi L, Zhang F. (2022). Structural characteristics of heparin binding to SARS-CoV-2 spike protein RBD of omicron sub-lineages BA. 2.12. 1, BA. 4 and BA. 5. Viruses, 14 (12), 2696.
Shi D, He P, Song Y, Cheng S, Linhardt RJ, Dordick JS, Chi L, Zhang F. (2022). Kinetic and Structural Aspects of Glycosaminoglycan–Monkeypox Virus Protein A29 Interactions Using Surface Plasmon Resonance. Molecules, 27 (18), 5898.
Kaur G, Song Y, Xia K, McCarthy K, Zhang F, Linhardt RJ, Harris NR. (2022). Effect of high glucose on glycosaminoglycans in cultured retinal endothelial cells and rat retina. Glycobiology, 320(8), 720-734.
Ahat E, Song Y, Xia K, Reid W, Li J, Bui S, Zhang F, Linhardt RJ, Wang Y. (2022). GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion. Cellular and Molecular Life Sciences, 79(4), 199.
Song Y, He P, Rodrigues AL, Datta P, Tandon R, Bates JT, Bierdeman MA, Chen C, Dordick J, Zhang F, Linhardt RJ. (2021). Anti-SARS-CoV-2 Activity of Rhamnan Sulfate from Monostroma nitidum. Marine Drugs, 19: 685
Patel VN, Pineda DL, Berenstein E, Hauser BR, Choi S, Prochazkova M, Zheng C, Goldsmith CM, Kuppevelt TH, Kulkarni A, Song Y, Linhardt RJ, Chibly AM, Hoffman MP. (2021). Loss of Hs3st3a1 or Hs3st3b1 enzymes alters heparan sulfate to reduce epithelial morphogenesis and adult salivary gland function. Matrix Biology, Vol 103–104: 37-57.
Song Y, Zhang F, Linhardt RJ. (2021). Glycosaminoglycans. In: Lauc G, Trbojević-Akmačić I. (eds) The Role of Glycosylation in Health and Disease. Advances in Experimental Medicine and Biology, vol 1325:103-116. Springer, Cham. https://doi.org/10.1007/978-3-030-70115-4_4.
Song Y, Qu Y, Cao X, Zhang W, Zhang F, Linhardt RJ, Yang Q. (2021). Cultivation of fractionated cells from a bioactive-alkaloid-bearing marine sponge Axinella sp.. In Vitro Cellular & Developmental Biology- Animal, 57: 539-549.
Yan L, Song Y, Xia k, He P, Zhang F, Chen S, Pouliot R, Weiss DJ, Tandon R, Bates JT, Ederer DR, Mitra D, Sharma P, Davis A, Linhardt RJ. (2021). Heparan sulfates from bat and human lung and their binding to the spike protein of SARS-CoV-2 virus. Carbohydrate Polymers, 260: 117797.
Song Y, Zhang F, Linhardt RJ. (2020). Analysis of the Glycosaminoglycan Chains of Proteoglycans. Journal of Histochemistry & Cytochemistry, 69 (2): 121-135.
Hu Y, Ren D, Song Y, Wu L, He Y, Peng Y, Zhou H, Liu S, Cong H, Zhang Z, Wang Q. (2020). Gastric protective activities of fucoidan from brown alga Kjellmaniella crassifolia through the NF-κB signaling pathway. International Journal of Biological Macromolecules, 149: 893-900.
Peng Y, Ren D, Song Y, Hu Y, Wu L, Wang Q, He Y, Zhou H, Liu S, Cong H. (2020). Effects of a combined fucoidan and traditional Chinese medicine formula on hyperglycaemia and diabetic nephropathy in a type II diabetes mellitus rat model. International Journal of Biological Macromolecules ,147 :408-419.
Ren D, Wang Q, Yang Y, Hu Y, Song Y, He Y, Liu S, Wu L. (2019). Hypolipidemic effects of fucoidan fractions from Saccharina sculpera (Laminariales, Phaeophyceae). International journal of biological macromolecules,140: 188-195.
Peng Y, Song Y, Wang Q, Hu Y, He Y, Ren D, Wu L, Liu S, Cong H, Zhou H. (2019). In vitro and in vivo immunomodulatory effects of fucoidan compound agents. International Journal of Biological Macromolecules, 127: 48-56.
Song Y, Wang Q, Wang Q, He Y, Ren D, Liu S, Wu L. (2018). Structural characterization and antitumor effects of fucoidans from brown algae Kjellmaniella crassifolia farmed in northern China. International Journal of Biological Macromolecules, 119: 125-133.
Liu S, Wang Q, Song Y, He Y, Ren D, Cong H, Wu L. (2018). Studies on the hepatoprotective effect of fucoidans from brown algae Kjellmaniella crassifolia. Carbohydrate Polymers, 193: 298-306.
Peng Y, Wang Y, Wang Q, Luo X, He Y, Song Y. (2018). Hypolipidemic effects of sulfated fucoidan from Kjellmaniella crassifolia through modulating the cholesterol and aliphatic metabolic pathways. Journal of Functional Foods, 51: 8-15.
Song Y, Wang Q, He Y, Ren D, Kow F, Li J, Liu S, Cong H. (2017). The positive effects of fucoidans extracted from the brown seaweed Saccharina japonica on protection against CCl4-induced liver injury. Journal of Applied Phycology, 29: 2077-2087.
Wang Q, Song Y, He Y, Ren D, Kow F, Qiao Z, Liu S, Yu X. (2014). Structural characterisation of algae Costaria costata fucoidan and its effects on CCl4-induced liver injury. Carbohydrate Polymers, 107: 247-254.
Song Y, Qu Y, Cao X, Zhang W. (2011). Cellular localization of debromohymenialdisine and hymenialdisine in the marine sponge Axinella sp. using a newly developed cell purification protocol. Marine Biotechnology, 13: 868-882.
Sun L, Song Y, Qu Y, Yu X, Zhang W. (2007). Purification and in vitro cultivation of archaeocytes (stem cells) of the marine sponge Hymeniacidon perleve (Demospongiae). Cell and Tissue Research, 328: 223-237.